Lamotrigine is used to treat the following conditions:
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Epilepsy is a brain disorder characterized by sudden, uncontrolled disturbances in the brain's electrical activity, leading to recurrent seizures (fits). These seizures can sometimes cause unconsciousness. In patients with epilepsy, the typical brain electrical patterns are disrupted by sudden bursts of electrical impulses that can affect consciousness, movements, or sensations.
Types of Seizures:
Symptoms:
Possible Causes:
Bipolar disorder, also known as manic depression or bipolar disease, is a mental health condition characterized by extreme mood swings. These mood swings include emotional highs (mania or hypomania) and lows (depression).
Symptoms of Mania:
Symptoms of Depression:
Effective management of bipolar disorder typically involves a combination of medication, therapy, and lifestyle changes.
Alcohol intake, along with Lamitrin ER 50, may cause increased dizziness and drowsiness. Please consult your doctor for more information.
Lamitrin ER 50 should be used with caution in women who are pregnant or planning to have a baby. Consult your doctor before taking it.
Lamitrin ER 50 should be used with caution in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it.
Do not drive or operate any machines if you experience dizziness, sleepiness, and other symptoms and signs of central nervous system depression after taking Lamitrin ER 50.
Lamitrin ER 50 should be taken with caution in patients with kidney impairment. Consult your doctor before taking it.
Lamitrin ER 50 should be taken with caution in patients with moderate to severe liver problems. Consult your doctor before taking it.
Lamitrin ER 50 Tablet manages:
It works by acting on ion channels in the brain and decreases the repetitive firing of brain cells.
Common Side Effects:
Uncommon Side Effects:
Rare Side Effects:
Serious Side Effects: Stop taking Lamitrin ER 50mg Tablet and contact your doctor immediately if you experience any of the following:
Nausea:
Vomiting:
Diarrhea:
Dry Mouth:
Headache:
Dizziness:
Skin Rash:
Blurred Vision:
Epilepsy-
Table-1: Escalation Regimen for Lamotrigine in Patients Older than 12 Years with Epilepsy
Weeks 1 & 2:
Weeks 3 & 4:
Week 5 onward to maintenance:
Usual maintenance dose:
Table-2: Escalation Regimen for Lamotrigine in Patients Aged 2 to 12 Years with Epilepsy
Weeks 1 & 2:
Weeks 3 & 4:
In patients not taking Carbamazepine, Phenytoin, Phenobarbital, Primidone, or Valproate: 0.6 mg/kg/day (in 2 divided doses)
Week 5 onward to maintenance:
Usual maintenance dose:
Table-3: The Initial Weight-Based Dosing Guide for Patients Aged 2 to 12 Years Taking Valproate (Weeks 1 to 4) with Epilepsy
Weeks 1 & 2:
Weeks 3 & 4:
Bipolar disorder-
Table-4: Escalation Regimen for Lamotrigine in Adults with Bipolar Disorder
Weeks 1 & 2:
Weeks 3 & 4:
Week 5:
Week 6:
Week 7:
Lamotrigine's specific mechanism of action is unknown, however it is thought to involve cellular actions that contribute to its efficacy in a variety of situations. Lamotrigine's activities are similar to those of phenytoin and carbamazepine, in that it inhibits voltage-sensitive sodium channels, stabilizes neuronal membranes, and modulates presynaptic excitatory neurotransmitter release.
Lamotrigine suppresses the release of the excitatory amino acid glutamate by blocking sodium currents by selectively binding to the inactive sodium channel.
Lamotrigine's mechanism of action in lowering anticonvulsant activity is most likely the same as it is in bipolar disorder treatment. Studies on lamotrigine have discovered that it binds to sodium channels in a similar way to local anesthetics, which could explain why it has been shown to help those with neuropathic pain.
Lamotrigine can connect to a variety of receptors.
Oral contraceptives, Atazanavir/ritonavir, Carbamazepine, Levetiracetam, Lithium, Lopinavir/ritonavir, Olanzapine, Phenobarbital/primidone, Phenytoin, Pregabalin, and others interact with Lamotrigine.
Dizziness, tremors, headache, rash, blurred vision, fever, lack of coordination, abdominal discomfort, infections, sleepiness, back pain, vomiting, diarrhea, weariness, sleeplessness, dry mouth, stuffy nose, and sore throat are all common Lamotrigine side effects.
Pregnancy Classification C. Human milk contains lamotrigine, which is expelled. Because Lamotrigine has the potential to produce major adverse reactions in nursing infants, a decision should be made whether to stop breastfeeding or stop taking the medicine, taking into account the drug's importance to the mother.
Both adults and children can develop serious skin rashes, blood dyscrasias, suicidal behavior, and aseptic meningitis.
Keep away from light and heat in a dry location. Keep out of children's reach.
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